Block Fat Absorption The lipase enzyme is answerable for fats absorption. Block it with a prescription drug known as Orlistat (Alli is the over-the-counter version). Take grams of a soluble fiber complement to half-hour before each major meal for extra assist. Five. Break Leptin Resistance Leptin is a hormone that tells your mind to prevent ingesting. But as we age, leptin has issue attending to the brain...That is known as leptin resistance.